期刊
NANOSCALE
卷 7, 期 6, 页码 2667-2675出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr06616b
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资金
- National Key Basic Research Program of China [2013CB933900, 2014CB744502]
- National Natural Science Foundation of China [21222106, 81370042, 81430041, 81472231, 81201805]
- Natural Science Foundation of Fujian [2013J06005]
- Fok Ying Tung Education Foundation [142012]
- National Key Sci-Tech Special Project of China [2012ZX10002-011-005]
Multifunctional nanostructures with both diagnostic and therapeutic capabilities have attracted considerable attention in biomedical research because they can offer great advantages in disease management and prognosis. In this work, a facile way to transfer the hydrophobic iron oxide (IO) nanoparticles into aqueous media by employing carboxylic graphene oxide (GO-COOH) as the transferring agent has been reported. In this one-step process, IO nanoparticles adhere to GO-COOH and form water-dispersible clusters via hydrophobic interactions between the hydrophobic ligands of IO nanoparticles and the basal plane of GO-COOH. The multiple IO nanoparticles on GO-COOH sheets (IO/GO-COOH) present a significant increase in T-2 contrast enhancement. Moreover, the IO/GO-COOH nanoclusters also display a high photothermal conversion efficiency and can effectively inhibit tumor growth through the photothermal effects. It is envisioned that such IO/GO-COOH nanocomposites combining efficient MRI and photothermal therapy hold great promise in theranostic applications.
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