期刊
NANOSCALE
卷 7, 期 14, 页码 6380-6387出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr00893j
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资金
- National Natural Science Foundation of China [51302180, 51222203, 51002100, 51132006]
- National 973 Program of China [2011CB911002, 2012CB932601]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Postdoctoral Research Program of Jiangsu Province [1202044C]
- Post-doctoral Science Foundation of China [2013M531400]
Recently, transition metal dichalcogenides (TMDCs) have attracted significant attention in nanomedicine owing to their intriguing properties. In this study, TiS2 nanosheets, a new TMDC nanomaterial, are synthesized by a bottom-up solution-phase method and then modified with polyethylene glycol (PEG), obtaining TiS2-PEG with high stability in physiological solutions and no appreciable in vitro toxicity. Due to their high absorbance in the near-infrared (NIR) region, TiS2-PEG nanosheets could offer a strong contrast in photoacoustic imaging, which uncovers the high tumor uptake and retention of these nanosheets after systemic administration into tumor-bearing mice. We further apply TiS2-PEG nanosheets for in vivo photothermal therapy, which are able to completely eradicate the tumors in mice upon intravenous injection of TiS2-PEG followed by NIR laser irradiation. Our work indicates that TiS2 nanosheets with appropriate surface coating (e.g. PEGylation) would be a promising new class of photothermal agents for imaging-guided cancer therapy.
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