期刊
NANOSCALE
卷 7, 期 28, 页码 11899-11903出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr01557j
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资金
- ERA.NET-RUS project [ST085 COPONAMRI]
- Universite de Montpellier
- CNRS
Cyano-bridged Gd3+/[Fe(CN)(6)](3-)coordination polymer nanoparticles of 3-4 nm stabilized with D-mannitol presenting a high r(1) relaxivity value of 11.4 mM(-1) s(-1) were investigated in vivo as contrast agents (CA) for Magnetic Resonance Imaging (MRI). They allow an increase of the MR image contrast and can act as an efficient intravascular T-1 CA with a relatively long blood-circulation lifetime (60 min) without specific toxicity.
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