期刊
NANOSCALE
卷 7, 期 5, 页码 1768-1775出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr06239f
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- Royal Society
- University College London
- Royal Institution of Great Britain
- AMAROUT-II Marie Curie Action under the European Commission's FP7 PEOPLE-COFUND program
- Royal Society of Chemistry
The adoption of magnetic hyperthermia as either a stand-alone or adjunct therapy for cancer is still far from being optimised due to the variable performance found in many iron oxide nanoparticle systems, including commercially available formulations. Herein, we present a reproducible and potentially scalable microwave-based method to make stable citric acid coated multi-core iron oxide nanoparticles, with exceptional magnetic heating parameters, viz. intrinsic loss parameters (ILPs) of up to 4.1 nH m(2) kg(-1), 35% better than the best commercial equivalents. We also probe the core-to-core magnetic interactions in the particles via remanence-derived Henkel and Delta M plots. These reveal a monotonic dependence of the ILP on the magnetic interaction field H-int, and show that the interactions are demagnetising in nature, and act to hinder the magnetic heating mechanism.
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