期刊
NANOSCALE
卷 7, 期 41, 页码 17244-17248出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr03373j
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资金
- Science & Engineering Research Council (SERC) of the Agency for Science, Technology and Research (A*STAR) [1021520014, 1021520015]
- School of Materials Science and Engineering
- Provost Office of NTU
Localized surface plasmon resonance (LSPR) biosensors typically suffer from diffusion limited mass transport and nonspecific adsorption upon detection of biomolecules in real biofluids. We employ here a peptide-modified plasmonic gold nanohole (AuNH) array for real-time detection of human troponin I (cTnI). Applying a negative electric bias on the AuNH sensor chip enables us to attract and concentrate cTnI at the sensor surface, while repelling other proteins thus decreasing interferences due to nonspecific adsorption.
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