期刊
NANOSCALE
卷 7, 期 47, 页码 20055-20062出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr06630a
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资金
- Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering
- National Institutes of Health
- National Key Program for Developing Basic Research of China [2014CB744501]
- NSFC [61271056, 61471168, 61527806]
- China Scholarship Council [201406090085]
A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the pi-pi stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.
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