期刊
NANOSCALE
卷 7, 期 14, 页码 5991-5997出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr06538g
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资金
- Swiss National Science Foundation [PP00P2_123373]
- Adolphe Merkle Foundation
- University of Fribourg
- L'Oreal Switzerland
- UNESCO's fellowship program For Women in Science
- Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials
- Swedish Research Council VR through the Linnaeus Center of Excellence on Organizing Molecular Matter
- European Commission [262348]
- Swiss National Science Foundation (SNF) [PP00P2_123373] Funding Source: Swiss National Science Foundation (SNF)
Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices - such as biological media and physiological fluids - light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the irrelevant ones is very challenging. We meet this challenge by building on depolarized scattering: Unwanted signals from the matrix are completely suppressed. This approach yields information with an unprecedented signal-to-noise ratio in favour of the NPs and NP-biomolecule corona complexes, which in turn opens the frontier to scattering-based studies addressing the behaviour of NPs in complex physiological/biological fluids.
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