期刊
NANOSCALE
卷 7, 期 6, 页码 2520-2526出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr06868h
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资金
- National Basic Research Program of China [2013CB733802, 2014CB744503, 2015CB931800, 2015CB931803]
- National Natural Science Foundation of China [81371596, 81401465, 81130028, 31210103913]
- Key Grant Project of Heilongjiang Province [GA12C302]
- Ph.D. Programs Foundation of Ministry of Education of China [201123071100203]
- Key Laboratory of Molecular Imaging Foundation(College of Heilongjiang Province)
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT), due to their specific spatiotemporal selectivity and minimal invasiveness, have been widely investigated as alternative treatments of malignant diseases. Graphene and its derivatives not only have been used as carriers to deliver photosensitizers for PDT, but also as photothermal conversion agents (PTCAs) for PTT. Herein, we strategically designed and produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated graphene oxide (GO-PEG-DVDMS) for enhanced fluorescence/photoacoustic (PA) dual-modal imaging and combined PDT and PTT. The GO-PEG carrier drastically improves the fluorescence of loaded DVDMS via intramolecular charge transfer. Concurrently, DVDMS significantly enhances the near-infrared (NIR) absorption of GO for improved PA imaging and PTT. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. This novel theranostics is well suited for fluorescence/PA dual-modal imaging and synergistic PDT/PTT.
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