期刊
NANOSCALE
卷 7, 期 22, 页码 10008-10012出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr01158b
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资金
- DBT-Wellcome Trust India Alliance and Innovative Young Biotechnologist Award
- CSIR, GoI
- NCBS
Here we tune the pH sensitivity of a DNA-based conformational switch, called the I-switch, to yield a set of fluorescent pH sensitive nanodevices with a collective, expanded pH sensing regime from 5.3 to 7.5. The expanded pH regime of this new family of I-switches originates from a dramatic improvement in the overall percentage signal change in response to pH of these nanodevices.
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