期刊
NANOSCALE
卷 7, 期 36, 页码 14989-14995出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr04244e
关键词
-
类别
资金
- Danish council for strategic research [11-115313]
- Aarhus University Research foundation
- China scholoarship Council
- Carlsberg Foundation
- Villum Fonden [00007194] Funding Source: researchfish
In the field of tissue engineering, integration of micro-porosity, nano-topogaphical features and weatt-ability into one three-dimensional (3D) scaffold remains a challenge. The extracellular matrix (ECM) mimicking feature of electrospun fibers endows them wide applications in tissue engineering. However, the tight-packing of electrospun submicron fibers hinder cell infiltration and further colonization. In this study, we fabricated hydrophilic, micro-porous scaffolds with nano-topographical cues by one-step electrospinning, and investigated NIH3T3 fibroblasts cell infiltration, colonization and myofibroblastic differentiation. The hierarchical porosity enhanced cell infiltration and proliferation significantly. Besides, the nano-topography influenced the cell actin distribution and cell morphology that stimulated myofibroblastic differentiation in a drastically different manner from that of traditional solid, smooth electrospun fibers, which may hold great potential in reconstructing tissues that require strong contractile forces.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据