期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 134, 期 1, 页码 25-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2014.03.014
关键词
Human rhinovirus; VP1; IgG(1) antibody; asthma exacerbation; children
资金
- National Health and Medical Research Council of Australia
- Australian Postgraduate Award
- University of Western Australia Scholarship
- Stan and Jean Perron Scholarship
- Asthma Foundation of Western Australia Scholarship
Background: Asthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C. We have previously shown that the HRV-C-specific antibody response is low in healthy adult sera and that most of the antibody to HRV-C is cross-reactive with HRV-A. Objectives: To compare the antibody response to each HRV species in asthmatic and nonasthmatic children in whom the type of HRV infection was known. Methods: Total and specific IgG(1) binding to HRV viral capsid protein antigens of HRV-A, -B, and -C were tested in the plasma from nonasthmatic children (n=47) and children presenting to the emergency department with asthma exacerbations (n=96). HRV, found in most of the children at the time of their exacerbation (72%), was analyzed using molecular typing. Results: Asthmatic children had higher antibody responses to HRV. The titers specific to HRV-A, and to a lesser extent HRV-B, were higher than in nonasthmatic controls. The species-specific responses to HRV-C were markedly lower than titers to HRV-A and HRV-B in both asthmatic and nonasthmatic children (P<.001). The titers both at presentation and after convalescence were not associated with the HRV genotype detected during the exacerbation. Conclusions: The higher total anti-HRV antibody titers of asthmatic children and their higher anti-HRV-A and -B titers show their development of a heightened antiviral immune response. The low species-specific HRV-C titers found in all groups, even when the virus was found, point to a different and possibly less efficacious immune response to this species.
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