期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 134, 期 1, 页码 12-19出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2014.05.026
关键词
HIV; latency; eradication; reservoir; cure; stem cell transplantation; antiretroviral therapy
资金
- Martin Delaney Collaboratory of AIDS Researchers for Eradication (US National Institutes of Health) [AI076113]
- Foundation for AIDS Research [108165 50 RGRL]
- Johns Hopkins Center for AIDS Research (US National Institutes of Health) [AI094189]
- US National Institutes of Health [AI43222]
- Howard Hughes Medical Institute
HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in resting CD4(+) T cells. This reservoir generally prevents cure of the infection with combination antiretroviral therapy alone. However, several recent cases of potential HIV-1 cure have generated renewed optimism. Here we review these cases and consider new developments in our understanding of the latent reservoir. In addition, we consider clinical aspects of curative strategies to provide a more realistic picture of what a generally applicable cure for HIV-1 infection is likely to entail.
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