期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 132, 期 2, 页码 264-286出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2013.05.044
关键词
Macrophage; dendritic cell; lipid; nuclear receptor; retinoid X receptor; retinoic acid receptor; peroxisome proliferator-associated receptor; liver X receptor; vitamin D receptor; rheumatoid arthritis; inflammatory bowel disease; systemic lupus erythematosus; asthma
资金
- National Excellence Program [TAMOP 4.2.4.A/2-11-1-2012-0001]
- European Union
- Hungarian Scientific Research Fund [OTKA K100196, TAMOP422_2012_0023]
- European Social Fund
- European Regional Development Fund
Nuclear receptors are ligand-activated transcription factors linking lipid signaling to the expression of the genome. There is increasing appreciation of the involvement of this receptor network in the metabolic programming of macrophages and dendritic cells (DCs), essential members of the innate immune system. In this review we focus on the role of retinoid X receptor, retinoic acid receptor, peroxisome proliferator-associated receptor g, liver X receptor, and vitamin D receptor in shaping the immune and metabolic functions of macrophages and DCs. We also provide an overview of the contribution of macrophage- and DC-expressed nuclear receptors to various immunopathologic conditions, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, asthma, and some others. We suggest that systematic analyses of the roles of these receptors and their activating lipid ligands in immunopathologies combined with complementary and focused translational and clinical research will be crucial for the development of new therapies using the many molecules available to target nuclear receptors.
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