Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle-peptide hybrids

A novel gold nanoparticle-peptide hybrid strategy was developed to intracellularly deliver a potent PKC delta inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle-peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides.