期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 11, 期 2, 页码 313-327出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2014.09.014
关键词
Biocompatibility; Mesoporous silica nanoparticles; Drug delivery systems; Biomedical applications
资金
- National Basic Research Program of China (973 Program) [2015CB932100]
- National Natural Science Foundation of China [81473165]
In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration. From the Clinical Editor: This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed. (C) 2015 Elsevier Inc. All rights reserved.
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