期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 127, 期 3, 页码 701-U317出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.11.050
关键词
Cytokines; interleukins; T cells; B cells; dendritic cells; adaptive immune response; humoral immune response; allergy and asthma
资金
- Swiss National Foundation
- Christine Kuhne Center for Allergy Research and Education
- Novartis
- Stallergenes
- Global Allergy and Asthma European Network
- Christine Kuhne Center for Allergy Research
Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among T-H and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-gamma. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections. (J Allergy Clin Immunol 2011;127:701-21.)
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