期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 11, 期 3, 页码 543-557出版社
ELSEVIER
DOI: 10.1016/j.nano.2014.11.003
关键词
Liposomes; Protein corona; Targeting
资金
- Futuro in Ricerca 2008 program - Italian Minister for University and Research [RBFR08TLPO]
- Istituto Italiano di Teconologia, Center for Life Nano Science@Sapienza
Active targeting that exploits the (over) expression of surface receptors in target cells by ligand incorporation is a central concept in nanomedicine research. Despite unprecedented efforts, no targeted liposome-based therapeutics is commercially available for clinical practice. What is inhibiting the efficient translation of targeted liposome technology from bench to bedside? After introduction in the bloodstream, the lipid surface is immediately modified by the adsorption of a protein corona and preserving the surface functionality appears to be challenging. On the other hand, a long-standing corona with receptor-binding sites could associate with the target cell long enough to activate the cell's uptake machinery, triggering liposome endocytosis and intracellular cargo delivery. This opens the intriguing possibility to manipulate the corona composition by liposome design. This review will focus on the emerging field of liposome-protein corona research from basic, descriptive research to readily applicable knowledge and technologies for implementation in drug improvement and development. (C) 2015 Elsevier Inc. All rights reserved.
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