期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 11, 期 3, 页码 671-679出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2014.10.005
关键词
Gold nanostars; Gold nanoconstructs; Aptamer; Toxicity; Biodistribution
资金
- National Institutes of Health Director's Pioneer Award [DP1OD003899]
- H Foundation Cancer Research Fund
- Malkin Scholar Award
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Department of Defense, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship [32 CFR 168a]
- NCI Cancer Center [2 P30 CA060553-19]
- National Science Foundation [CHE-9810378/005]
- NASA Ames Research Center [NNA06CB93G]
- Cancer Center Support Grant [NCI CA060553]
- [FA9550-11-C-0028]
This paper reports an in vivo evaluation of toxicology and biodistribution of a highly anisotropic Au nanoconstruct composed of a gold nanostar (AuNS) core and a ligand shell of a G-quadruplex DNA aptamer AS1411 (Apt) supporting both targeting and therapy capabilities. We examined the toxicity of the nanoconstructs (Apt-AuNS) at four different injected concentrations. At the highest dose tested (48 mg/kg), maximal tolerated dose was not reached. Clinical pathology showed no apparent signs of acute toxicity. Interestingly, the nanoconstructs circulated longer in female rats compared to male rats. In two different tumor models, the biodistribution of Apt-AuNS, especially tumor accumulation, was different. Accumulation of Apt-AuNS was 5 times higher in invasive breast cancer tumors compared to fibrosarcoma tumors. These results provide insight on identifying a tumor model and nanoconstruct for in vivo studies, especially when an in vitro therapeutic response is observed in multiple cancer cell lines. (C) 2015 Elsevier Inc. All rights reserved.
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