期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 127, 期 4, 页码 875-882出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.11.031
关键词
Asthma symptoms; atopy; distance; traffic; particulate matter; spirometry
资金
- Johns Hopkins Center
- Fogarty International Center [R24 TW007988]
- Johns Hopkins University [K99/R00]
- National Heart, Lung, and Blood Institute [K99HL096955]
- National Institutes of Health [HHSN268200900033C]
- Mary Beryl Patch Turnbull Scholar Program
- Tufts University School of Medicine
- NIH [T35AI065385]
- National Institute for Environmental Health Sciences [ES015903, ES03819]
- National Institutes of Health
- Sanofi-Aventis
Background: Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes. Objective: We sought to determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a periurban shantytown in Lima, Peru. Methods: We enrolled 725 adolescents aged 13 to 15 years who were administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing, and exhaled nitric oxide (eNO). We calculated distances from the main avenue for all households and measured indoor particulate matter in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO levels, and FEV1/forced vital capacity ratio as a function of distance. Results: Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (P < .05). The odds of atopy increased by a factor of 1.07 for every 100-meter difference in the distance from the avenue (P = .03). We found an inverse relationship in prebronchodilator FEV1/forced vital capacity and distance to the avenue in female subjects (P = .01) but not in male subjects. We did not find an association between eNO or household particulate matter levels and distance. Conclusion: Living in close proximity to a high-traffic-density avenue in a periurban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile-source pollutants in periurban areas of developing countries might help reduce the burden of asthma symptoms and atopy. (J Allergy Clin Immunol 2011;127:875-82.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据