期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 127, 期 3, 页码 576-586出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.12.1116
关键词
Oral tolerance; regulatory T cell; forkhead box protein 3; dendritic cell; food allergy; microbiota; vitamin A; TGF-beta; CD103
资金
- National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID)
- Thrasher Research Fund
- Cephalon
- NIH
- National Peanut Board
- NIH/NIAID
- DYAX Corp
- Food Allergy Initiative
- FAAN
- Wallace Research Foundation
The intestine has an unenviable task: to identify and respond to a constant barrage of environmental stimuli that can be both dangerous and beneficial. The proper execution of this task is central to the homeostasis of the host, and as a result, the gastrointestinal tract contains more lymphocytes than any other tissue compartment in the body, as well as unique antigen-presenting cells with specialized functions. When antigen is initially encountered through the gut, this system generates a robust T cell-mediated hyporesponsiveness called oral tolerance. Although seminal observations of oral tolerance were made a century ago, the relevant mechanisms are only beginning to be unraveled with the use of modern investigational techniques. Food allergy is among the clinical disorders that occur from a failure of this system, and therapies that seek to re-establish tolerance are currently under investigation. (J Allergy Clin Immunol 2011;127:576-84.)
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