期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 126, 期 6, 页码 1099-U60出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.08.035
关键词
Mast cells; tryptase; histamine; mastocytosis; allergy; anaphylaxis; urticaria
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich (FWF) [P21173-B13, SFB-F01820]
- Food Allergy Initiative
- Novartis
- Bristol-Myers Squibb
The term mast cell activation syndrome (MCAS) is finding increasing use as a diagnosis for subjects who present with signs and symptoms involving the dermis, gastrointestinal track, and cardiovascular system frequently accompanied by neurologic complaints. Such patients often have undergone multiple extensive medical evaluations by different physicians in varied disciplines without a definitive medical diagnosis until the diagnosis of MCAS is applied. However, MCAS as a distinct clinical entity has not been generally accepted, nor do there exist definitive criteria for diagnosis. Based on current understanding of this disease syndrome and on what we do know about mast cell activation and resulting pathology, we will explore and propose criteria for its diagnosis. The proposed criteria will be discussed in the context of other disorders involving mast cells or with similar presentations and as a basis for further scientific study and validation. (J Allergy Clin Immunol 2010;126:1099-104.)
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