期刊
Nanomedicine-Nanotechnology Biology and Medicine
卷 11, 期 6, 页码 1417-1423出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2015.02.023
关键词
Ag nanoparticle-based antimicrobial films; Supersonic cluster beam deposition; Atomic force microscopy; Electron spectroscopies; Bactericidal activity; Extensively drug-resistant bacteria
资金
- Universita Cattolica del Sacro Cuore [D2.2]
The recent emergence of bacterial pathogens resistant to most or all available antibiotics is among the major global public health problems. As indirect transmission through contaminated surfaces is a main route of dissemination for most of such pathogens, the implementation of effective antimicrobial surfaces has been advocated as a promising approach for their containment, especially in the hospital settings. However, traditional wet synthesis methods of nanoparticle-based antimicrobial materials leave a number of key points open for metal surfaces: such as adhesion to the surface and nanoparticle coalescence. Here we demonstrate an alternative route, i.e. supersonic cluster beam deposition, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces. The synthesized films are simple to produce with controlled density and thickness, are stable over time, and are shown to be highly bactericidal against major Gram positive and Gram negative bacterial pathogens, including extensively drug-resistant strains. From the Clinical Editor: The use of silver nanoparticle in health care is getting more widespread. The authors here describe the technique of cluster beam deposition for spraying silver on surfaces used in health care sectors. This may open a new avenue for future anti-bacterial coatings. (C) 2015 The Authors. Published by Elsevier Inc.
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