期刊
NANOMEDICINE
卷 10, 期 13, 页码 2051-2061出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.15.52
关键词
magnetoelectric nanoparticles; nanoengineering the brain; noninvasive brain stimulation
资金
- National Science Foundation (NSF) [ECCS-1408063, IIP-1237818]
- NIH DA [R01DA034547-01]
- Department of Defense (DoD) Defense Microelectronics Activity (DMEA) [H94003-09-2-0904]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1408063] Funding Source: National Science Foundation
Aim: The in vivo study on imprinting control region mice aims to show that magnetoelectric nanoparticles may directly couple the intrinsic neural activity-induced electric fields with external magnetic fields. Methods: Approximately 10 mu g of CoFe2O4-BaTiO3 30-nm nanoparticles have been intravenously administrated through a tail vein and forced to cross the blood-brain barrier via a d.c. field gradient of 3000 Oe/cm. A surgically attached two-channel electroencephalography headmount has directly measured the modulation of intrinsic electric waveforms by an external a.c. 100-Oe magnetic field in a frequency range of 0-20 Hz. Results: The modulated signal has reached the strength comparable to that due the regular neural activity. Conclusion: The study opens a pathway to use multifunctional nanoparticles to control intrinsic fields deep in the brain.
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