期刊
NANOMEDICINE
卷 10, 期 8, 页码 1263-1274出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.14.211
关键词
doxorubicin; hyaluronic acid; hydrogel; intratumoral; Pluronic F127
资金
- National Science Council of the Republic of China [NS 102-2320-B-038-017]
- Technology Development Program for Academia, Ministry of Economic Affairs, Republic of China [102-EC-17-A-20-S1-200]
Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic((R)) F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.
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