期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 123, 期 6, 页码 1253-1259出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2009.03.007
关键词
Asthma; allergy; atopy; folate; National Health and Nutrition Examination Survey; Centers for Disease Control
资金
- National Institute of Allergy and Infectious Diseases [R01A1070630]
- National Institutes of Environmental Health Sciences [5P50ES015903]
Background: Folic acid is known to be associated with inflammatory diseases, but the relationship between folic acid and allergic diseases is unclear. Objectives: The purpose of the study was to examine the relationship between serum folate levels and markers of atopy, wheeze, and asthma. Methods: Data were obtained from the 2005-2006 National Health and Nutrition Examination Survey in which serum folate and total IgE levels were measured in 8083 subjects 2 years of age and older. A high total IgE level was defined as greater than 100 kU/L. Allergen-specific IgE levels were measured for a panel of 5 common aeroallergens. Atopy was defined as at least 1 positive allergen-specific IgE level. Doctor-diagnosed asthma and wheeze in the previous 12 months were assessed by means of questionnaire. Results: Serum folate levels were inversely associated with total IgE levels (P < .001). The odds of a high total IgE level, atopy, and wheeze decreased across quintiles of serum folate levels, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity, and poverty index ratio. Adjusted odds ratios associated with the fifth quintile of folate relative to the first quintile were as follows: high IgE level, 0.70 (95% CI, 0.53-0.92); atopy, 0.69 (95% CI, 0.57-0.85); and wheeze, 0.60 (95% CI, 0.44-0.82). Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma, but this finding was not statistically significant (odds ratio for fifth quintile vs first quintile, 0.84 [95% CI, 0.70-1.02]). Conclusions: Serum folate levels are inversely associated with high total IgE levels, atopy, and wheeze. (J Allergy Clin Immunol 2009;123:1253-9.)
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