期刊
NANOMEDICINE
卷 10, 期 18, 页码 2833-2845出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.113
关键词
hMSCs; human mesenchymal stem cells; microtissues; MTs; nanofibrous collagen implant; osteoarticular regeneration; regenerative nanomedicine
资金
- Agence Nationale de la Recherche, ANR
- SATT Conectus
- 'Faculte de Chirurgie Dentaire' Strasbourg
Aim: Articular cartilage repair remains challenging, because most clinical failures are due to the lack of subchondral bone regeneration. We report an innovative approach improving cartilage repair by regenerating a robust subchondral bone, supporting articular cartilage. Materials & methods: We developed a compartmented living implant containing triple-3D structure: stem cells as microtissues for embryonic endochondral development mimic, nanofibrous collagen to enhance mineralization for subchondral bone and alginate hydrogel for cartilage regeneration. Results & conclusion: This system mimics the natural gradient of the osteochondral unit, using only one kind of stem cell, targeting their ability to express specific bone or cartilage proteins. Mineralization gradient of articular cartilage and the natural 'glue' between subchondral bone and cartilage were reproduced in vitro.
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