期刊
NANOMEDICINE
卷 10, 期 8, 页码 1315-1326出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.14.219
关键词
bottom-up synthesis; gold; nanoparticle; nanoparticle functionalization; nanoparticle stability; organelle targeting
资金
- Engineering and Physical Sciences Research Council [1232311] Funding Source: researchfish
With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
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