期刊
NANO RESEARCH
卷 8, 期 12, 页码 3982-3991出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-015-0901-0
关键词
hydrothermal; ammonium ion-intercalated 1T-WS2; ultrathin nanosheets; biocompatibility; photostability; photothermal therapy
类别
资金
- National Basic Research Program of China [2012CB825800, 2014CB848900, 2014CB932500]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [11321503]
- National Natural Science Foundation of China [11321503, U1232131, U1532112, 51222202, 91123010, 11574280]
- Fundamental Research Funds for the Central Universities [WK2310000035]
In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH (4) (+) intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.
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