期刊
NANO LETTERS
卷 15, 期 12, 页码 8354-8359出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b04045
关键词
fluorescence enhancement; DNA origami; single-molecule detection; plasmonics; gold nanoparticles
类别
资金
- European Research Council (ERC) [EU 261162]
- Deutsche Forschungsgesellschaft [AC 279/2-1, TI 329/9-1, GRK 1952/1]
- Studienstiftung des Deutschen Volkes
Optical nanoantennas are known to focus freely propagating light and reversely to mediate the emission of a light source located at the nanoantenna hotspot. These effects were previously exploited for fluorescence enhancement and single-molecule detection at elevated concentrations. We present a new generation of self-assembled DNA origami based optical nanoantennas with improved robustness, reduced interparticle distance, and optimized quantum-yield improvement to achieve more than 5000-fold fluorescence enhancement and single-molecule detection at 25 mu M background fluorophore concentration. Besides outperforming lithographic optical antennas, DNA origami nanoantennas are additionally capable of incorporating single emitters or biomolecular assays at the antenna hotspot.
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