期刊
NANO LETTERS
卷 16, 期 1, 页码 138-144出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03331
关键词
nanopores; tRNA; single molecule; RNA; SVM
类别
资金
- National Institutes of Health [HG006873, HG 006323, GM080376]
It has been hypothesized that the ribosome gains additional fidelity during protein translation by probing structural differences in tRNA species. We measure the translocation kinetics of different tRNA species through similar to 3 nm diameter synthetic nanopores. Each tRNA species varies in the time scale with which it is deformed from equilibrium, as in the translocation step of protein translation. Using machine-learning algorithms, we can differentiate among five tRNA species, analyze the ratios of tRNA binary mixtures, and distinguish tRNA isoacceptors.
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