期刊
NANO LETTERS
卷 15, 期 10, 页码 6559-6567出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b02286
关键词
Multiplexed bioelectronic nose; graphene micropatterns; field-effect transistor; olfactory receptor; human mimicking; odorant discrimination
类别
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) grant - Ministry of Science, ICT and future Planning [2014053108]
- Korea Government (MEST) [2011-0017125]
- KRIBB Initiative Research Program (KRIBB, Korea)
Human sensory-mimicking systems, such as electronic brains, tongues, skin, and ears, have been promoted for use in improving social welfare. However, no significant achievements have been made in mimicking the human nose due to the complexity of olfactory sensory neurons. Combinational coding of human olfactory receptors (hORs) is essential for odorant discrimination in mixtures, and the development of hOR-combined multiplexed systems has progressed slowly. Here, we report the first demonstration of an artificial multiplexed superbioelectronic nose (MSB-nose) that mimics the human olfactory sensory system, leading to high-performance odorant discriminatory ability in mixtures. Specifically, portable MSB-noses were constructed using highly uniform graphene micropatterns (GMs) that were conjugated with two different hORs, which were employed as transducers in a liquid-ion gated field-effect transistor (PET). Field-induced signals from the MSB-nose were monitored and provided high sensitivity and selectivity toward target odorants (minimum detectable level: 0.1 fM). More importantly, the potential of the MSB-nose as a tool to encode hOR combinations was demonstrated using principal component analysis.
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