期刊
NANO LETTERS
卷 15, 期 12, 页码 8311-8315出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03935
关键词
Enzymes; catalysis; microparticles; micromotors; diffusion; chemotaxis
类别
资金
- Penn State MRSEC under NSF [DMR-1420620]
- NSF CAREER [CBET-1055284]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1055284] Funding Source: National Science Foundation
Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene micropartides were functionalized with the enzymes urease and catalase using a biotin streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.
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