期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 38, 页码 9968-9975出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b03040
关键词
diosgenin; hypertriacylglycerolemia; oral fat tolerance test; lipoprotein lipase
资金
- Japan Society for the Promotion of Science (JSPS) [16H03041]
In this study, we examined the fasted and postprandial triacylglycerol (TG) levels in ICK-A(Y) mice fed a high-fat diet (HFD) or a HFD containing either 500 ppm (0.05%) of diosgenin or 500 ppm (0.05%) of diosgenin-containing Chinese yam sanyaku. Oral fat tolerance tests revealed that, not only in the fasting state but also after loading of lipid emulsion, plasma levels of TG were significantly reduced in sanyaku- and diosgenin- fed mice. Levels of fat oxidation, especially in the dark phase (from 7 p.m. to 7 a.m.), were increased in the sanyaku and diosgenin groups. Moreover mRNA levels of lipoprotein lipase and peroxisome proliferator-activated receptor gamma, coactivator l alpha were moderately upregulated in the liver of sanyaku- and diosgenin-ingested mice. These results suggest that consecutive ingestion of diosgenin or diosgenin-containing sanyaku at the dose achievable in a human diet potentially ameliorates fasted and postprandial hypertriacylglycerolemia, which could be associated with the improvement of TG metabolism.
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