期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 40, 页码 10388-10393出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b02057
关键词
limonin; metabolism; reduction; hydrolysis
资金
- National Natural Science Foundation of China [81403174, 81774096]
- Natural Science Foundation of Jiangsu Province [BK20161610, BK20151602]
- Jiangsu Provincial Medical Youth Talent [QNRC2016642]
- Chinese Talented Person Training Project for China Association of Chinese Medicine [QNRC2-B04]
- Science and Technology Projects of Jiangsu Province Hospital of Traditional Chinese Medicine [Y18010]
- Top Six Talent Project of Jiangsu Province 2016 [WSN-051]
Limonin is a triterpenoid in citrus seeds, which has significant biological activities. However, the metabolic profile of limonin has not been fully understood. To expound its metabolism in vivo and in vitro, the metabolites of limonin was studied by rat liver microsomes, urine, and bile. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used for identification. Among the metabolites, the structures of M1 and M3 were confirmed by chemical synthesis and nuclear magnetic resonance spectra analysis. Our results indicated that reduction and hydrolysis were the two major pathways during limonin metabolism in vivo and in vitro. The results from this work are valuable and important for understanding the metabolic process of limonin.
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