期刊
NANO LETTERS
卷 15, 期 2, 页码 1146-1151出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl504217p
关键词
Conductive polymers; hydrogel; biosensor; human metabolite; uric acid; cholesterol; triglyceride
类别
资金
- University of Texas at Austin
- Welch Foundation [F-1861]
- Chinese National Key Fundamental Research Project [2013CB932900, 2011CB92210]
- National Natural Science Foundation of China [61229401, 61076017, 60990314, 41401257]
- Natural Science Fundation of Jiangsu [BK2011011, BK20130055, BK20141054]
- NCET Program
- PAPD Program
The development of a scalable, low-cost, and versatile biosensor platform for the sensitive and rapid detection of human metabolites is of great interest for healthcare, pharmaceuticals, and medical science. On the basis of hierarchically nanostructured conducting polymer hydrogels, we designed a flexible biosensor platform that can detect various human metabolites, such as uric acid, cholesterol, and triglycerides. Owing to the unique features of conducting polymer hydrogels, such as high permeability to biosubstrates and rapid electron transfer, our biosensors demonstrate excellent sensing performance with a wide linear range (uric acid, 0.07-1 mM; cholesterol, 0.39 mM, and triglycerides, 0.25 mM), high sensitivity, low sensing limit, and rapid response time (similar to 3 s). Given the facile and scalable processability of hydrogels, the proposed conductive hydrogels-based biosensor platform shows great promise as a low-cost sensor kit for healthcare monitoring, clinical diagnostics, and biomedical devices.
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