期刊
NANO LETTERS
卷 15, 期 2, 页码 842-848出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl5045378
关键词
Gold nanoparticles; liposomes; photothermal therapy; cancer nanotechnology; theranostics
类别
资金
- TMC Seed-in-Air Intramural
- DBT Bioengineering research grant
- IIT-B Healthcare initiative
We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs) capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of LiposAu NPs performed in a small animal model indicates in situ degradation in hepatocytes and further getting cleared through the hepato-biliary and renal route. Further, the therapeutic potential of LiposAu NPs tested in mouse tumor xenograft model using NIR laser (750 nm) illumination resulted in complete ablation of the tumor mass, thus prolonging disease-free survival.
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