期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 4, 页码 885-892出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf404318j
关键词
Perilla frutescens; supramolecular formation; rosmarinic acid extract; antioxidant activity; antiallergic activity; alpha-glucosidase inhibitory activity
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology
Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from Perilla leaves. By the supramolecular complex which was formed from flavocommelin and Perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. Rosmarinic acid extract (62.9 +/- 4.5% purity) was partly purified by partitioning ethyl acetate and water. Rosmarinic acid extract exhibited high total phenolic content of 433.9 +/- 58.6 mu g/mg of gallic acid equivalent, effective DPPH radical scavenging activity (SC50 of 5.5 +/- 0.2 mu g/mL), antiallergic activity (IC50 of 52.9 +/- 6.7 mu g/mL), and a-glucosidase inhibitory activity (IC50 of 0.23 +/- 0.01 mg/mL). Rosmarinic acid extract shows high potential for diabetes mellitus and allergy treatments by inhibiting a-glucosidase activity and measuring beta-hexosaminidase, related to life-style disease.
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