期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 11, 页码 2364-2373出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf405032f
关键词
purple sweet potato anthocyanins; biochemical parameters; histopathological analysis; dealcoholic effect; alcoholic liver damage
资金
- Earmarked Fund for the China Agriculture Research System [CARS-11-B-19]
- Fundamental Research Funds for Incremental Project Budget of Chinese Academy of Agricultural Sciences [2013ZL014]
- Crop Nutrition and Processing Characteristics Research Project of Chinese Academy of Agricultural Sciences
- Support Plan of National Science and Technology-the Suitability Evaluation and Special Varieties Screening of Sweet Potato [2012BAD29B03-03]
This study aimed to investigate the dealcoholic effect and preventive effect of anthocyanins from purple sweet potato (PSPAs) on acute and subacute alcoholic liver damage (ALD). Seven-week-old male inbred mice were grouped into five groups: control group (without PSPAs and ethanol treatments), model group (with ethanol treatment only), low-dose group (50 mg PSPAs/kg body weight), middle-dose group (125 mg PSPAs/kg body weight), and high-dose group (375 mg PSPAs/kg body weight), and the mice in all groups were administered intragastrically. Biochemical parameters of serum and liver were determined, and the histopathological changes of liver tissue were also analyzed. Results showed that all tested parameters were ameliorated after consumption of PSPAs. Therefore, PSPAs have preventive effect on acute and subacute ALD. It is suggested that PSPAs could be used as a supplementary reagent during prophylactic and curative managements of ALD.
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