期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 40, 页码 9944-9951出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf5031218
关键词
nuclear magnetic resonances; fiber; metabolomics; gut microbiota; gut flora-host interactions; microbial metabolic activity
资金
- DuPont
- Food Future Innovation (FFI)
- Aarhus University
- Danish research council FTP [274-09-0107]
The aim of the present study was to elucidate the impact of polydextrose PDX an soluble fiber, on the human fecal metabolome by high-resolution nuclear magnetic resonance (NMR) spectroscopy-based metabolomics in a dietary intervention study (n = 12). Principal component analysis (PCA) revealed a strong effect of PDX consumption on the fecal metabolome, which could be mainly ascribed to the presence of undigested fiber and oligosaccharides formed from partial degradation of PDX. Our results demonstrate that NMR-based metabolomics is a useful technique for metabolite profiling of feces and for testing compliance to dietary fiber intake in such trials. In addition, novel associations between PDX and the levels of the fecal metabolites acetate and propionate could be identified. The establishment of a correlation between the fecal metabolome and levels of Bifidobacterium (R-2 = 0.66) and Bacteroides (R-2 = 0.46) demonstrates the potential of NMR-based metabolomics to elucidate metabolic activity of bacteria in the gut.
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