期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 28, 页码 6632-6639出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf501006y
关键词
comet assay; DNA topology assay; DPPH radicals scavenging assay; Fe2+-chelating assay; hydroxyl radicals scavenging assay; plant essential oil components; reducing power assay; Rosmarinus officinalis oil
资金
- Scientific Grant Agency of the Ministry of Education of Slovak Republic
- Academy of Sciences (VEGA) [1/0025/11, 2/0012/12, 1/0053/14]
- Slovak Research and Development Agency [APVV-0040-10]
Selected components of plant essential oils and intact Rosmarinus officinalis oil (RO) were investigated for their antioxidant, iron-chelating, and DNA-protective effects. Antioxidant activities were assessed using four different techniques. DNA-protective effects on human hepatoma HepG2 cells and plasmid DNA were evaluated with the help of the comet assay and the DNA topology test, respectively. It was observed that whereas eugenol, carvacrol, and thymol showed high antioxidative effectiveness in all assays used, RO manifested only antiradical effect and borneol and eucalyptol did not express antioxidant activity at all. DNA-protective ability against hydrogen peroxide (H2O2)-induced DNA lesions was manifested by two antioxidants (carvacrol and thymol) and two compounds that do not show antioxidant effects (RO and borneol). Borneol was able to preserve not only DNA of HepG2 cells but also plasmid DNA against Fe2+-induced damage. This paper evaluates the results in the light of experiences of other scientists.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据