期刊
NANO LETTERS
卷 15, 期 12, 页码 8032-8043出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03370
关键词
Lymph node resection; Cerenkov-guided surgery; combination therapy
类别
资金
- Prostate Cancer Foundation
- Alex's Lemonade Stand Foundation
- Starr Cancer Consortium [I4-A427]
- NIH [1R01CA183953-01A1, R01EB014944, 1 S10 OD016207-01]
- National Science Foundation [DGS 0965983]
- Department of Defense Prostate Cancer Research Program of the Congressionally Directed Medical Research Programs [W81XWH-12-1-0509]
- MSKCC NIH Core Grant [P30-CA008748]
- MSKCC's Experimental Therapeutics Center
- Commonwealth Foundation for Cancer Research
- Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center
- Center of Molecular Imaging and Nanotechnology
Novel multifunctional platforms are needed for oncology in order to assist physicians during surgery and chemotherapy. In the present study, we show that polymeric nanobeacons, consisting of the glucose-based polymer dextran, can be used to guide surgery and improve drug delivery. For imaging, the nanobeacons stably retained the positron emitter 89-zirconium and the MRI contrast agent gadolinium, without the need of a chelator. In addition to using them for PET imaging, the Zr-89-nanobeacons guided the surgical resection of sentinel lymph nodes, utilizing their inherent Cerenkov luminescence. Through weak electrostatic interactions, the nanoparticles carried combinations of chemotherapeutics for the simultaneous inhibition of oncogenic pathways, resulting in enhanced tumor regression. The nanobeacons also allowed monitoring of drug release via MRI, through the quenching of the gadolinium signal by the coloaded drug, making them a new multifunctional theranostic nanotechnology platform for the clinic.
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