期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 61, 期 4, 页码 829-839出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf3048498
关键词
turbulent flow chromatography (TFC); ultrahigh-performance liquid chromatography (UHPLC); Orbitrap high-resolution mass spectrometry (HRMS); multiclass analysis; veterinary drugs; honey
资金
- Spanish Ministry of Economy and Competitiveness (MINECO)
- FEDER [AGL2010-21370, AP2008-02811]
- Juan de la Cierva Program
- Ramon y Cajal Program (MINECO-ESF)
A simple and rapid method is described for the determination of veterinary drug (VD) residues in honey samples using turbulent flow chromatography coupled to ultrahigh-performance liquid chromatography-Orbitrap mass spectrometry (TFC-UHPLC-Orbitrap-MS). Honey samples were diluted with an aqueous solution of Na(2)EDTA (0.1 M). Then, they were injected into the chromatographic system including a TFC column. Afterward, the analytes were transferred to an UHPLC analytical column, where they were determined by UHPLC-Orbitrap-MS. Mean recoveries were obtained at three concentration levels (5, 10, and 50 mu g/kg), ranging from 68 to 121% for most compounds. Repeatability (intraday precision) and interday precision (expressed as relative standard deviation, RSD) were <2596 for most compounds. Limits of quantification (LOQs) ranged from 5 to 50 mu g/kg and limits of identification (LOIs) from 0.1 to 50 mu g/kg. The developed method was applied in honey samples, and it was fast and nonlaborious.
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