期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 61, 期 19, 页码 4606-4613出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf305395n
关键词
differential accessibility; food dye; BSA; electrostatic interaction; molecular docking
资金
- DST-India [SR/FTP/CS-97/2006]
- CSIR-India [01/(2177)/07 EMR-II]
- IIT-Kharagpur (ISIRD-EEM grant)
- UGC India
- CSIR
- IIT-Kharagpur
Our recent report on the binding of Cochineal Red A, a food dye, with HSA and BSA at pH 7.4 has revealed that electrostatic forces is the principal cause of interaction. In that study issues relating to complications arising out of modulation of dye binding affinity of BSA with pH had not been explored. Here we have further explored the interaction of Cochineal Red A with BSA in pH range 4.8-7.8. Surprisingly, this system behaves differently in the texture of interaction pattern at two extremes of studied pH range, unlike HSA Importantly, the charge on the amino acid side chains in the binding pocket is likely to play a significant role.
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