4.7 Article

Galacto-oligosaccharides Derived from Lactulose Exert a Selective Stimulation on the Growth of Bifidobacterium animalis in the Large Intestine of Growing Rats

期刊

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 61, 期 31, 页码 7560-7567

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jf402218z

关键词

bifidobacteria; Bifidobacterium animalis; galacto-cligosaccharides; gut microbiota; lactulose; prebiotic

资金

  1. Spanish Council for Scientific Research (CSIC) from the Ministerio de Ciencia e Innovacion [PIF-SIALOBIOTIC 200870F010-1, PIF-SIALOBIOTIC 200870F010-2, PIF-SIALOBIOTIC 200870F010-3]
  2. ERDF from Junta de Comunidades de Castilla-La Mancha [POII10-0178-4685]
  3. Junta de Andalucia [AGR-7626]
  4. Spanish National Research Council (CSIC, JAE-Doc Programme)
  5. COST Action

向作者/读者索取更多资源

There is increasing interest in identifying novel dietary nondigestible carbohydrates capable of modulating the composition and/or metabolic activities of the gut microbiota. This work assessed the differential modulatory influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu) in comparison with commercial galacto-oligosaccharides derived from lactose (GOS-La) in gut microbiota of growing rats (5 weeks old). Rats were fed either a control diet or diets containing 1% (w/w) of GOS-Lu or GOS-La, and cecal and colonic contents were collected after 14 days of treatment. Compared to controls, GOS-Lu had significantly more bifidobacteria within the large intestine, showing a significant and selective increase of Bifidobacterium animalis in the cecum and colon; however, no significant differences in the number of bifidobacteria among GOSLu and GOS-La groups were observed. Both types of GOS significantly increased the number of the Eubacterium rectale/Clostridium coccoides group. These findings support a prebiotic role of galactosyl-fructoses in functional foods.

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