期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 61, 期 28, 页码 6982-6990出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf401724w
关键词
Fuzhuan brick-tea; dark tea; Camellia sinensis var. sinensis; fuzhuanin A; fuzhuanin B; B-ring fission lactones; HPLC analysis; antiproliferative activity; HeLa cells; enteric pathogenic microbes; antibacterial activity
资金
- Modern Agro-Industry Technology Research System
- National Natural Science Foundation of China [31101335]
- Natural Science Foundation of Anhui Province [10040606Q19]
- Key Research Foundation of Science and Technology, Ministry of Education, P. R. China [209058]
- Ministry of Agriculture and Ministry of Finance, People's Republic of China
Fuzhuan brick-tea is a special dark tea prepared from the leaves of Camellia sinensis var. sinensis. Its production involves a fungal fermentation stage, which forms the unique flavors and functions by a series of biochemical reactions. Our phytochemical research of the material led to the isolation of two new B-ring fission lactones of flavan-3-ols, fuzhuanins A (1) and B (2). In addition, three other flavan-3-ol derivatives (3-5), three flavone C-glycosides (6-8), eight flavonoid O-glycosides (10-17), five simple phenolics (19-23), two norisoprenoid glycosides (24, 25), two sesquiterpenoids (26, 27), and theobromine (28), as well as two flavonoid anions (9 and 18), were also identified. The structures of these compounds were determined by spectroscopic methods. Compounds 4, 19, 20, 22-24, 26, and 27 were reported for the first time in Camellia spp. and tea. Furthermore, HPLC analysis method was performed to compare the chemical constituents of the before/after fungal fermentation Fuzhuan brick-teas. Compound 1 was indicated as one of the major characteristic constituents generated in the fungal fermentation process. The IC50 value of the antiproliferative activity of 2 on He La cells was assayed as 4.48 mu M. None of the isolated compounds showed any inhibition activity against the enteric pathogenic microbes at 800 mu g/mL by the hole plate diffusion method.
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