期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 61, 期 19, 页码 4551-4555出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf400212y
关键词
Cladosporium cladosporioides; antifungal; Colletotrichum species; Phomopsis species; cladosporin; anthracnose
资金
- National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH) [P20GM104931]
- NIH National Center for Research Resources [C06 RR-14503-01]
- Conselho Nacional of Desenvolvimento Cientifico and Tecnologico (CNPq)
Bioassay-guided fractionation of Cladosporium cladosporioides (Fresen.) de Vries extracts led to the isolation of four compounds, including cladosporin, 1; isocladosporin, 2; 5'-hydroxyasperentin, 3; and cladosporin-8-methyl ether, 4. An additional compound, 5',6-diacetylcladosporin, 5, was synthesized by acetylation of compound 3. Compounds 1-5 were evaluated for antifungal activity against plant pathogens. Phomopsis viticola was the most sensitive fungus to the tested compounds. At 30 mu M, compound 1 exhibited 927, 90.1, 95.4, and 79.9% growth inhibition against Colletotrichum acutatum, Colletotrichum fragariae, Colletotrichum gloeosporioides, and P. viticola, respectively. Compound 2 showed 50.4, 60.2, and 83.0% growth inhibition at 30 mu M against Co. fragariae, Co. gloeosporioides, and P. viticola, respectively. Compounds 3 and 4 were isolated for the first time from Cl. cladosporioides. Moreover, the identification of essential structural features of the cladosporin nuclei has also been evaluated. These structures provide new templates for the potential treatment and management of plant diseases.
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