期刊
NANO LETTERS
卷 15, 期 12, 页码 8217-8222出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03728
关键词
Conducting polymer; nanoshell; polymer brush; swface initiated polymerization; dedoping resistance; antifouling capability
类别
资金
- NIH [R01CA170734, U19ES019545, R01EB016034]
- Washington Life Sciences Discovery Fund [3292512]
- UW Bioengineering Department
Despite broad applications ranging from electronics to biomedical sensing and imaging, a long-standing problem of conducting polymers is the poor resistance to dedoping, which directly affects their signature electrical and optical properties. This problem is particularly significant for biomedical uses because of fast leaching of dopant ions in physiological environments. Here, we describe a new approach to engineer multimodal core shell nanopartides with a stably doped conductive polymer shell in biological environments. It was achieved by making a densely packed polymer brush rather than changing its molecular structure. Polyaniline (PANT) was used as a model compound due to its concentrated near-infrared (NIR) absorption. It was grafted onto a magnetic nanoparticle via a polydopamine intermediate layer. Remarkably, at pH 7 its conductivity is ca. 2000X higher than conventional PANT nanoshells. Similarly, its NIR absorption is enhanced by 2 orders of magnitude, ideal for photothermal imaging and therapy. Another surprising finding is its nonfouling property, even outperforming polyethylene glycol. This platform technology is also expected to open exciting opportunities in engineering stable conductive materials for electronics, imaging, and sensing.
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