期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 33, 页码 8146-8154出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf300928j
关键词
immunomodulation; IL-10; phycobiliproteins; red seaweeds
资金
- Ministery of Science and Innovation [SAF2008-01432, AGL2008-04332]
- Junta de Andalucia [CTS-6736, CTS164]
- Fundacion Ramon Areces
- Erasmus Mundus External Cooperation Window
- Ministery of Education and Science of Spain
- Universidad Nacional del Litoral [2009-PI-54-258]
- Instituto de Salud Carlos III
The phycobiliproteins from Rhodophyta, R-phycoerythrin (R-PE) and C-phycocyanin (C-PC), have been shown to exert immunomodulatory effects. This study evaluated the effects of a Phorphyra columbina protein fraction (PF) and R-PE and C-PC on rat primary splenocytes, macrophages, and T-lymphocytes in vitro. PF featured various protein species, including R-PE and C-PC. PF showed mitogenic effects on rat splenocytes and was nontoxic to cells except at 1 g L-1 protein. IL-10 secretion was enhanced by PF in rat splenocytes, macrophages, and especially T-lymphocytes, whereas it was markedly diminished by R-PE and C-PC. The production of pro-inflammatory cytokines by macrophages was inhibited. The effect of PF on IL-10 was evoked by JNK/p38 MAPK and NF-kappa B-dependent pathways in macrophages and T-lymphocytes. It was concluded that PF has immunomodulatory effects on macrophages and lymphocytes that appear to be predominantly anti-inflammatory via up-regulated IL-10 production and cannot be accounted for by R-PE and C-PC.
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