期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 45, 页码 11331-11342出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf303165w
关键词
Flavonoids; catechins; phenolic acids; gut microbiota; metabolism; metabolomics
资金
- European Community under the Marie Curie Transfer of Knowledge-Industry-Academia Strategic Partnership Scheme [MTKICT-2006-042786]
The colonic microbial degradation of a polyphenol-rich black tea extract (BTE) and red wine/grape juice extract (RWGE) was compared in a five-stage in vitro gastrointestinal model (TWINSHIME). Microbial metabolism of BTE and RWGE polyphenols in the TWINSHIME was studied subsequently in single- and continuous dose experiments. A combination of liquid or gas Chromatography with Mass spectrometry (LC-MS or GC-MS) and NMR-based metabolic profiling was used to measure selected parent polyphenols, their microbial degradation into phenolic acids, and the production of short-chain fatty acids (SCFAs) in different colon compartments. Acetate production was increased by Continuous feeding of BTE but not RWGE. During RWGE feeding; gallic acid: and 4-hydroxyphenylpropionic acid remained elevated throughout the colon, while during BTE feeding, they were consumed in the distal colon, while 3-phenylpropionic acid was strongly produced. Gut microbial production of phenolics and SCFAs is dependent on colon location and polyphenol source, which may influence potential health benefits.
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