期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 29, 页码 7152-7157出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf301047f
关键词
EGCG; DCQA; lipase inhibition; green tea; coffee; Ligularia fischeri; simulated digestion
资金
- Korea Institute of Science and Technology Gangneung Institute [2Z03560]
- National Research Council of Science & Technology (NST), Republic of Korea [2Z0356] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus making their beneficial effects doubtful. This study was conducted,to evaluate the inhibitory effect of three beverages on lipolysis and the contribution of their major polyphenols during simulated digestion. During simulated digestion, gomchui tea was the most potent at inhibiting gastrointestinal lipolysis, whereas green tea was the least potent. The strongest lipase inhibitor among purified major polyphenols was a green tea polyphenol, (-)-epigallocatechin gallate (EGCG, IC50 = 1.8 +/- 0.57 mu M), followed by di-O-caffeoylquinic acid isomers (DCQA, IC50 from 12.7 +/- 4.5 to 404 +/- 23 mu M), which are gomchui tea polyphenols. However, the stability of DCQA was greater than that of EGCG when subjected to simulated digestion. Taken together, gomchui tea, which has DCQA as the major polyphenol, showed stronger lipolysis inhibitory activity during simulated digestion compared to both green tea and coffee.
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